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Risk Factors for Severe Outcomes following 2009 Influenza A (H1N1) Infection: A Global Pooled Analysis

Identifieur interne : 006041 ( Main/Exploration ); précédent : 006040; suivant : 006042

Risk Factors for Severe Outcomes following 2009 Influenza A (H1N1) Infection: A Global Pooled Analysis

Auteurs : Maria D. Van Kerkhove [Royaume-Uni] ; Katelijn A. H. Vandemaele ; Vivek Shinde ; Giovanna Jaramillo-Gutierrez ; Artemis Koukounari [Royaume-Uni] ; Christl A. Donnelly [Royaume-Uni] ; Luis O. Carlino [Argentine] ; Rhonda Owen [Australie] ; Beverly Paterson [Australie] ; Louise Pelletier [Canada] ; Julie Vachon [Canada] ; Claudia Gonzalez [Chili] ; Yu Hongjie [République populaire de Chine] ; Feng Zijian [République populaire de Chine] ; Shuk Kwan Chuang [Hong Kong] ; Albert Au [Hong Kong] ; Silke Buda [Allemagne] ; Gerard Krause [Allemagne] ; Walter Haas [Allemagne] ; Isabelle Bonmarin [France] ; Kiyosu Taniguichi [Japon] ; Kensuke Nakajima [Japon] ; Tokuaki Shobayashi [Japon] ; Yoshihiro Takayama [Japon] ; Tomi Sunagawa [Japon] ; Jean Michel Heraud [Madagascar] ; Arnaud Orelle [Madagascar] ; Ethel Palacios [Mexique] ; Marianne A. B. Van Der Sande [Pays-Bas] ; C. C. H. Lieke Wielders [Pays-Bas] ; Darren Hunt [Nouvelle-Zélande] ; Jeffrey Cutter [Singapour] ; Vernon J. Lee [Singapour] ; Juno Thomas [Afrique du Sud] ; Patricia Santa-Olalla [Espagne] ; Maria J. Sierra-Moros [Espagne] ; Wanna Hanshaoworakul [Thaïlande] ; Kumnuan Ungchusak [Thaïlande] ; Richard Pebody [Royaume-Uni] ; Seema Jain [États-Unis] ; Anthony W. Mounts

Source :

RBID : PMC:3130021

Abstract

This study analyzes data from 19 countries (from April 2009 to Jan 2010), comprising some 70,000 hospitalized patients with severe H1N1 infection, to reveal risk factors for severe pandemic influenza, which include chronic illness, cardiac disease, chronic respiratory disease, and diabetes.


Url:
DOI: 10.1371/journal.pmed.1001053
PubMed: 21750667
PubMed Central: 3130021


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<name sortKey="Owen, Rhonda" sort="Owen, Rhonda" uniqKey="Owen R" first="Rhonda" last="Owen">Rhonda Owen</name>
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<name sortKey="Au, Albert" sort="Au, Albert" uniqKey="Au A" first="Albert" last="Au">Albert Au</name>
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<name sortKey="Taniguichi, Kiyosu" sort="Taniguichi, Kiyosu" uniqKey="Taniguichi K" first="Kiyosu" last="Taniguichi">Kiyosu Taniguichi</name>
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<addr-line>Ministry of Health, Labour and Welfare, Tokyo, Japan</addr-line>
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</affiliation>
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<name sortKey="Takayama, Yoshihiro" sort="Takayama, Yoshihiro" uniqKey="Takayama Y" first="Yoshihiro" last="Takayama">Yoshihiro Takayama</name>
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<addr-line>Ministry of Health, Labour and Welfare, Tokyo, Japan</addr-line>
</nlm:aff>
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<name sortKey="Sunagawa, Tomi" sort="Sunagawa, Tomi" uniqKey="Sunagawa T" first="Tomi" last="Sunagawa">Tomi Sunagawa</name>
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<addr-line>Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan</addr-line>
</nlm:aff>
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<name sortKey="Heraud, Jean Michel" sort="Heraud, Jean Michel" uniqKey="Heraud J" first="Jean Michel" last="Heraud">Jean Michel Heraud</name>
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<nlm:aff id="aff13">
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</author>
<author>
<name sortKey="Orelle, Arnaud" sort="Orelle, Arnaud" uniqKey="Orelle A" first="Arnaud" last="Orelle">Arnaud Orelle</name>
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<nlm:aff id="aff13">
<addr-line>Virology Unit, Institut Pasteur from Madagascar, Antananarivo, Madagascar</addr-line>
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<country xml:lang="fr">Madagascar</country>
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</affiliation>
</author>
<author>
<name sortKey="Palacios, Ethel" sort="Palacios, Ethel" uniqKey="Palacios E" first="Ethel" last="Palacios">Ethel Palacios</name>
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<addr-line>Directorate General of Epidemiology, Mexico City, Mexico</addr-line>
</nlm:aff>
<country xml:lang="fr">Mexique</country>
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<author>
<name sortKey="Van Der Sande, Marianne A B" sort="Van Der Sande, Marianne A B" uniqKey="Van Der Sande M" first="Marianne A. B." last="Van Der Sande">Marianne A. B. Van Der Sande</name>
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<nlm:aff id="aff15">
<addr-line>Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea>
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</affiliation>
</author>
<author>
<name sortKey="Wielders, C C H Lieke" sort="Wielders, C C H Lieke" uniqKey="Wielders C" first="C. C. H. Lieke" last="Wielders">C. C. H. Lieke Wielders</name>
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<nlm:aff id="aff15">
<addr-line>Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands</addr-line>
</nlm:aff>
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</author>
<author>
<name sortKey="Hunt, Darren" sort="Hunt, Darren" uniqKey="Hunt D" first="Darren" last="Hunt">Darren Hunt</name>
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<nlm:aff id="aff16">
<addr-line>New Zealand Ministry of Health, Wellington, New Zealand</addr-line>
</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
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</author>
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<name sortKey="Cutter, Jeffrey" sort="Cutter, Jeffrey" uniqKey="Cutter J" first="Jeffrey" last="Cutter">Jeffrey Cutter</name>
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<nlm:aff id="aff17">
<addr-line>Communicable Diseases Division at the Ministry of Health, Singapore</addr-line>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Communicable Diseases Division at the Ministry of Health</wicri:regionArea>
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</author>
<author>
<name sortKey="Lee, Vernon J" sort="Lee, Vernon J" uniqKey="Lee V" first="Vernon J." last="Lee">Vernon J. Lee</name>
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<nlm:aff id="aff18">
<addr-line>Biodefence Centre, Ministry of Defence, Singapore</addr-line>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Biodefence Centre, Ministry of Defence</wicri:regionArea>
<wicri:noRegion>Ministry of Defence</wicri:noRegion>
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<affiliation wicri:level="4">
<nlm:aff id="aff19">
<addr-line>Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</addr-line>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
</author>
<author>
<name sortKey="Thomas, Juno" sort="Thomas, Juno" uniqKey="Thomas J" first="Juno" last="Thomas">Juno Thomas</name>
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<nlm:aff id="aff20">
<addr-line>Epidemiology and Surveillance Unit, Respiratory Virus Unit, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa</addr-line>
</nlm:aff>
<country xml:lang="fr">Afrique du Sud</country>
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</affiliation>
</author>
<author>
<name sortKey="Santa Olalla, Patricia" sort="Santa Olalla, Patricia" uniqKey="Santa Olalla P" first="Patricia" last="Santa-Olalla">Patricia Santa-Olalla</name>
<affiliation wicri:level="3">
<nlm:aff id="aff21">
<addr-line>Coordinating Centre for Health Alerts and Emergencies, Dirección General de Salud Pública y Sanidad Exterior Ministerio de Sanidad y Política Social, Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
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</affiliation>
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<name sortKey="Sierra Moros, Maria J" sort="Sierra Moros, Maria J" uniqKey="Sierra Moros M" first="Maria J." last="Sierra-Moros">Maria J. Sierra-Moros</name>
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<nlm:aff id="aff21">
<addr-line>Coordinating Centre for Health Alerts and Emergencies, Dirección General de Salud Pública y Sanidad Exterior Ministerio de Sanidad y Política Social, Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Coordinating Centre for Health Alerts and Emergencies, Dirección General de Salud Pública y Sanidad Exterior Ministerio de Sanidad y Política Social, Madrid</wicri:regionArea>
<placeName>
<settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hanshaoworakul, Wanna" sort="Hanshaoworakul, Wanna" uniqKey="Hanshaoworakul W" first="Wanna" last="Hanshaoworakul">Wanna Hanshaoworakul</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<addr-line>Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand</addr-line>
</nlm:aff>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Department of Disease Control, Ministry of Public Health, Nonthaburi</wicri:regionArea>
<wicri:noRegion>Nonthaburi</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ungchusak, Kumnuan" sort="Ungchusak, Kumnuan" uniqKey="Ungchusak K" first="Kumnuan" last="Ungchusak">Kumnuan Ungchusak</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<addr-line>Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand</addr-line>
</nlm:aff>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Department of Disease Control, Ministry of Public Health, Nonthaburi</wicri:regionArea>
<wicri:noRegion>Nonthaburi</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Pebody, Richard" sort="Pebody, Richard" uniqKey="Pebody R" first="Richard" last="Pebody">Richard Pebody</name>
<affiliation wicri:level="3">
<nlm:aff id="aff23">
<addr-line>Health Protection Agency, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Health Protection Agency, London</wicri:regionArea>
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<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Jain, Seema" sort="Jain, Seema" uniqKey="Jain S" first="Seema" last="Jain">Seema Jain</name>
<affiliation wicri:level="2">
<nlm:aff id="aff24">
<addr-line>Epidemiology and Prevention Branch, Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Epidemiology and Prevention Branch, Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea>
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<region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mounts, Anthony W" sort="Mounts, Anthony W" uniqKey="Mounts A" first="Anthony W." last="Mounts">Anthony W. Mounts</name>
<affiliation>
<nlm:aff id="aff1">
<addr-line>Global Influenza Programme, World Health Organization</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">World Health Organization</wicri:noCountry>
</affiliation>
</author>
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<title xml:lang="en" level="a" type="main">Risk Factors for Severe Outcomes following 2009 Influenza A (H1N1) Infection: A Global Pooled Analysis</title>
<author>
<name sortKey="Van Kerkhove, Maria D" sort="Van Kerkhove, Maria D" uniqKey="Van Kerkhove M" first="Maria D." last="Van Kerkhove">Maria D. Van Kerkhove</name>
<affiliation>
<nlm:aff id="aff1">
<addr-line>Global Influenza Programme, World Health Organization</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">World Health Organization</wicri:noCountry>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="aff2">
<addr-line>Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Vandemaele, Katelijn A H" sort="Vandemaele, Katelijn A H" uniqKey="Vandemaele K" first="Katelijn A. H." last="Vandemaele">Katelijn A. H. Vandemaele</name>
<affiliation>
<nlm:aff id="aff1">
<addr-line>Global Influenza Programme, World Health Organization</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">World Health Organization</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Shinde, Vivek" sort="Shinde, Vivek" uniqKey="Shinde V" first="Vivek" last="Shinde">Vivek Shinde</name>
<affiliation>
<nlm:aff id="aff1">
<addr-line>Global Influenza Programme, World Health Organization</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">World Health Organization</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Jaramillo Gutierrez, Giovanna" sort="Jaramillo Gutierrez, Giovanna" uniqKey="Jaramillo Gutierrez G" first="Giovanna" last="Jaramillo-Gutierrez">Giovanna Jaramillo-Gutierrez</name>
<affiliation>
<nlm:aff id="aff1">
<addr-line>Global Influenza Programme, World Health Organization</addr-line>
</nlm:aff>
<wicri:noCountry code="subfield">World Health Organization</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Koukounari, Artemis" sort="Koukounari, Artemis" uniqKey="Koukounari A" first="Artemis" last="Koukounari">Artemis Koukounari</name>
<affiliation wicri:level="3">
<nlm:aff id="aff2">
<addr-line>Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Donnelly, Christl A" sort="Donnelly, Christl A" uniqKey="Donnelly C" first="Christl A." last="Donnelly">Christl A. Donnelly</name>
<affiliation wicri:level="3">
<nlm:aff id="aff2">
<addr-line>Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Council Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Carlino, Luis O" sort="Carlino, Luis O" uniqKey="Carlino L" first="Luis O." last="Carlino">Luis O. Carlino</name>
<affiliation wicri:level="1">
<nlm:aff id="aff3">
<addr-line>Ministerio de Salud de la Nación, Buenos Aires, Argentina</addr-line>
</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Ministerio de Salud de la Nación, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Owen, Rhonda" sort="Owen, Rhonda" uniqKey="Owen R" first="Rhonda" last="Owen">Rhonda Owen</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<addr-line>Influenza Surveillance Section, Surveillance Branch, Office of Health Protection, Department of Health and Ageing, Woden, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Influenza Surveillance Section, Surveillance Branch, Office of Health Protection, Department of Health and Ageing, Woden</wicri:regionArea>
<wicri:noRegion>Woden</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Paterson, Beverly" sort="Paterson, Beverly" uniqKey="Paterson B" first="Beverly" last="Paterson">Beverly Paterson</name>
<affiliation wicri:level="1">
<nlm:aff id="aff4">
<addr-line>Influenza Surveillance Section, Surveillance Branch, Office of Health Protection, Department of Health and Ageing, Woden, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Influenza Surveillance Section, Surveillance Branch, Office of Health Protection, Department of Health and Ageing, Woden</wicri:regionArea>
<wicri:noRegion>Woden</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Pelletier, Louise" sort="Pelletier, Louise" uniqKey="Pelletier L" first="Louise" last="Pelletier">Louise Pelletier</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<addr-line>Influenza Surveillance Section, Public Health Agency of Canada, Ontario, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Influenza Surveillance Section, Public Health Agency of Canada, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Vachon, Julie" sort="Vachon, Julie" uniqKey="Vachon J" first="Julie" last="Vachon">Julie Vachon</name>
<affiliation wicri:level="1">
<nlm:aff id="aff5">
<addr-line>Influenza Surveillance Section, Public Health Agency of Canada, Ontario, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Influenza Surveillance Section, Public Health Agency of Canada, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Gonzalez, Claudia" sort="Gonzalez, Claudia" uniqKey="Gonzalez C" first="Claudia" last="Gonzalez">Claudia Gonzalez</name>
<affiliation wicri:level="1">
<nlm:aff id="aff6">
<addr-line>Departamento de Epidemiología, División de Planificación Sanitaria, Ministerio de Salud de Chile, Santiago, Chile</addr-line>
</nlm:aff>
<country xml:lang="fr">Chili</country>
<wicri:regionArea>Departamento de Epidemiología, División de Planificación Sanitaria, Ministerio de Salud de Chile, Santiago</wicri:regionArea>
<wicri:noRegion>Santiago</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hongjie, Yu" sort="Hongjie, Yu" uniqKey="Hongjie Y" first="Yu" last="Hongjie">Yu Hongjie</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<addr-line>Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention Beijing</wicri:regionArea>
<wicri:noRegion>Chinese Center for Disease Control and Prevention Beijing</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Zijian, Feng" sort="Zijian, Feng" uniqKey="Zijian F" first="Feng" last="Zijian">Feng Zijian</name>
<affiliation wicri:level="1">
<nlm:aff id="aff7">
<addr-line>Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Office for Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention Beijing</wicri:regionArea>
<wicri:noRegion>Chinese Center for Disease Control and Prevention Beijing</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Chuang, Shuk Kwan" sort="Chuang, Shuk Kwan" uniqKey="Chuang S" first="Shuk Kwan" last="Chuang">Shuk Kwan Chuang</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<addr-line>Surveillance and Epidemiology Branch, Centre for Health Protection, Centre for Health Protection of Department of Health, Hong Kong</addr-line>
</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Surveillance and Epidemiology Branch, Centre for Health Protection, Centre for Health Protection of Department of Health</wicri:regionArea>
<wicri:noRegion>Centre for Health Protection of Department of Health</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Au, Albert" sort="Au, Albert" uniqKey="Au A" first="Albert" last="Au">Albert Au</name>
<affiliation wicri:level="1">
<nlm:aff id="aff8">
<addr-line>Surveillance and Epidemiology Branch, Centre for Health Protection, Centre for Health Protection of Department of Health, Hong Kong</addr-line>
</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Surveillance and Epidemiology Branch, Centre for Health Protection, Centre for Health Protection of Department of Health</wicri:regionArea>
<wicri:noRegion>Centre for Health Protection of Department of Health</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Buda, Silke" sort="Buda, Silke" uniqKey="Buda S" first="Silke" last="Buda">Silke Buda</name>
<affiliation wicri:level="3">
<nlm:aff id="aff9">
<addr-line>Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin</wicri:regionArea>
<placeName>
<region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Krause, Gerard" sort="Krause, Gerard" uniqKey="Krause G" first="Gerard" last="Krause">Gerard Krause</name>
<affiliation wicri:level="3">
<nlm:aff id="aff9">
<addr-line>Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin</wicri:regionArea>
<placeName>
<region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Haas, Walter" sort="Haas, Walter" uniqKey="Haas W" first="Walter" last="Haas">Walter Haas</name>
<affiliation wicri:level="3">
<nlm:aff id="aff9">
<addr-line>Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department for Infectious Disease Epidemiology, Robert Koch Institute, Berlin</wicri:regionArea>
<placeName>
<region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bonmarin, Isabelle" sort="Bonmarin, Isabelle" uniqKey="Bonmarin I" first="Isabelle" last="Bonmarin">Isabelle Bonmarin</name>
<affiliation wicri:level="1">
<nlm:aff id="aff10">
<addr-line>Département des Maladies Infectieuses, Institut de Veille, Sanitaire, Saint-Maurice Cedex, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Département des Maladies Infectieuses, Institut de Veille, Sanitaire, Saint-Maurice Cedex</wicri:regionArea>
<wicri:noRegion>Saint-Maurice Cedex</wicri:noRegion>
<wicri:noRegion>Saint-Maurice Cedex</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Taniguichi, Kiyosu" sort="Taniguichi, Kiyosu" uniqKey="Taniguichi K" first="Kiyosu" last="Taniguichi">Kiyosu Taniguichi</name>
<affiliation wicri:level="3">
<nlm:aff id="aff11">
<addr-line>Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo</wicri:regionArea>
<placeName>
<settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Nakajima, Kensuke" sort="Nakajima, Kensuke" uniqKey="Nakajima K" first="Kensuke" last="Nakajima">Kensuke Nakajima</name>
<affiliation wicri:level="3">
<nlm:aff id="aff12">
<addr-line>Ministry of Health, Labour and Welfare, Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Ministry of Health, Labour and Welfare, Tokyo</wicri:regionArea>
<placeName>
<settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Shobayashi, Tokuaki" sort="Shobayashi, Tokuaki" uniqKey="Shobayashi T" first="Tokuaki" last="Shobayashi">Tokuaki Shobayashi</name>
<affiliation wicri:level="3">
<nlm:aff id="aff12">
<addr-line>Ministry of Health, Labour and Welfare, Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Ministry of Health, Labour and Welfare, Tokyo</wicri:regionArea>
<placeName>
<settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Takayama, Yoshihiro" sort="Takayama, Yoshihiro" uniqKey="Takayama Y" first="Yoshihiro" last="Takayama">Yoshihiro Takayama</name>
<affiliation wicri:level="3">
<nlm:aff id="aff12">
<addr-line>Ministry of Health, Labour and Welfare, Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Ministry of Health, Labour and Welfare, Tokyo</wicri:regionArea>
<placeName>
<settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Sunagawa, Tomi" sort="Sunagawa, Tomi" uniqKey="Sunagawa T" first="Tomi" last="Sunagawa">Tomi Sunagawa</name>
<affiliation wicri:level="3">
<nlm:aff id="aff11">
<addr-line>Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan</addr-line>
</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo</wicri:regionArea>
<placeName>
<settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Heraud, Jean Michel" sort="Heraud, Jean Michel" uniqKey="Heraud J" first="Jean Michel" last="Heraud">Jean Michel Heraud</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<addr-line>Virology Unit, Institut Pasteur from Madagascar, Antananarivo, Madagascar</addr-line>
</nlm:aff>
<country xml:lang="fr">Madagascar</country>
<wicri:regionArea>Virology Unit, Institut Pasteur from Madagascar, Antananarivo</wicri:regionArea>
<wicri:noRegion>Antananarivo</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Orelle, Arnaud" sort="Orelle, Arnaud" uniqKey="Orelle A" first="Arnaud" last="Orelle">Arnaud Orelle</name>
<affiliation wicri:level="1">
<nlm:aff id="aff13">
<addr-line>Virology Unit, Institut Pasteur from Madagascar, Antananarivo, Madagascar</addr-line>
</nlm:aff>
<country xml:lang="fr">Madagascar</country>
<wicri:regionArea>Virology Unit, Institut Pasteur from Madagascar, Antananarivo</wicri:regionArea>
<wicri:noRegion>Antananarivo</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Palacios, Ethel" sort="Palacios, Ethel" uniqKey="Palacios E" first="Ethel" last="Palacios">Ethel Palacios</name>
<affiliation wicri:level="1">
<nlm:aff id="aff14">
<addr-line>Directorate General of Epidemiology, Mexico City, Mexico</addr-line>
</nlm:aff>
<country xml:lang="fr">Mexique</country>
<wicri:regionArea>Directorate General of Epidemiology, Mexico City</wicri:regionArea>
<wicri:noRegion>Mexico City</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Van Der Sande, Marianne A B" sort="Van Der Sande, Marianne A B" uniqKey="Van Der Sande M" first="Marianne A. B." last="Van Der Sande">Marianne A. B. Van Der Sande</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">
<addr-line>Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea>
<wicri:noRegion>Bilthoven</wicri:noRegion>
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</author>
<author>
<name sortKey="Wielders, C C H Lieke" sort="Wielders, C C H Lieke" uniqKey="Wielders C" first="C. C. H. Lieke" last="Wielders">C. C. H. Lieke Wielders</name>
<affiliation wicri:level="1">
<nlm:aff id="aff15">
<addr-line>Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Epidemiology and Surveillance Unit, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea>
<wicri:noRegion>Bilthoven</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hunt, Darren" sort="Hunt, Darren" uniqKey="Hunt D" first="Darren" last="Hunt">Darren Hunt</name>
<affiliation wicri:level="1">
<nlm:aff id="aff16">
<addr-line>New Zealand Ministry of Health, Wellington, New Zealand</addr-line>
</nlm:aff>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>New Zealand Ministry of Health, Wellington</wicri:regionArea>
<wicri:noRegion>Wellington</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Cutter, Jeffrey" sort="Cutter, Jeffrey" uniqKey="Cutter J" first="Jeffrey" last="Cutter">Jeffrey Cutter</name>
<affiliation wicri:level="1">
<nlm:aff id="aff17">
<addr-line>Communicable Diseases Division at the Ministry of Health, Singapore</addr-line>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Communicable Diseases Division at the Ministry of Health</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Lee, Vernon J" sort="Lee, Vernon J" uniqKey="Lee V" first="Vernon J." last="Lee">Vernon J. Lee</name>
<affiliation wicri:level="1">
<nlm:aff id="aff18">
<addr-line>Biodefence Centre, Ministry of Defence, Singapore</addr-line>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Biodefence Centre, Ministry of Defence</wicri:regionArea>
<wicri:noRegion>Ministry of Defence</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="aff19">
<addr-line>Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</addr-line>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
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</author>
<author>
<name sortKey="Thomas, Juno" sort="Thomas, Juno" uniqKey="Thomas J" first="Juno" last="Thomas">Juno Thomas</name>
<affiliation wicri:level="1">
<nlm:aff id="aff20">
<addr-line>Epidemiology and Surveillance Unit, Respiratory Virus Unit, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa</addr-line>
</nlm:aff>
<country xml:lang="fr">Afrique du Sud</country>
<wicri:regionArea>Epidemiology and Surveillance Unit, Respiratory Virus Unit, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg</wicri:regionArea>
<wicri:noRegion>Johannesburg</wicri:noRegion>
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</author>
<author>
<name sortKey="Santa Olalla, Patricia" sort="Santa Olalla, Patricia" uniqKey="Santa Olalla P" first="Patricia" last="Santa-Olalla">Patricia Santa-Olalla</name>
<affiliation wicri:level="3">
<nlm:aff id="aff21">
<addr-line>Coordinating Centre for Health Alerts and Emergencies, Dirección General de Salud Pública y Sanidad Exterior Ministerio de Sanidad y Política Social, Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Coordinating Centre for Health Alerts and Emergencies, Dirección General de Salud Pública y Sanidad Exterior Ministerio de Sanidad y Política Social, Madrid</wicri:regionArea>
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<settlement type="city">Madrid</settlement>
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<author>
<name sortKey="Sierra Moros, Maria J" sort="Sierra Moros, Maria J" uniqKey="Sierra Moros M" first="Maria J." last="Sierra-Moros">Maria J. Sierra-Moros</name>
<affiliation wicri:level="3">
<nlm:aff id="aff21">
<addr-line>Coordinating Centre for Health Alerts and Emergencies, Dirección General de Salud Pública y Sanidad Exterior Ministerio de Sanidad y Política Social, Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Coordinating Centre for Health Alerts and Emergencies, Dirección General de Salud Pública y Sanidad Exterior Ministerio de Sanidad y Política Social, Madrid</wicri:regionArea>
<placeName>
<settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
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</author>
<author>
<name sortKey="Hanshaoworakul, Wanna" sort="Hanshaoworakul, Wanna" uniqKey="Hanshaoworakul W" first="Wanna" last="Hanshaoworakul">Wanna Hanshaoworakul</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<addr-line>Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand</addr-line>
</nlm:aff>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Department of Disease Control, Ministry of Public Health, Nonthaburi</wicri:regionArea>
<wicri:noRegion>Nonthaburi</wicri:noRegion>
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</author>
<author>
<name sortKey="Ungchusak, Kumnuan" sort="Ungchusak, Kumnuan" uniqKey="Ungchusak K" first="Kumnuan" last="Ungchusak">Kumnuan Ungchusak</name>
<affiliation wicri:level="1">
<nlm:aff id="aff22">
<addr-line>Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand</addr-line>
</nlm:aff>
<country xml:lang="fr">Thaïlande</country>
<wicri:regionArea>Department of Disease Control, Ministry of Public Health, Nonthaburi</wicri:regionArea>
<wicri:noRegion>Nonthaburi</wicri:noRegion>
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</author>
<author>
<name sortKey="Pebody, Richard" sort="Pebody, Richard" uniqKey="Pebody R" first="Richard" last="Pebody">Richard Pebody</name>
<affiliation wicri:level="3">
<nlm:aff id="aff23">
<addr-line>Health Protection Agency, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Health Protection Agency, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
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</author>
<author>
<name sortKey="Jain, Seema" sort="Jain, Seema" uniqKey="Jain S" first="Seema" last="Jain">Seema Jain</name>
<affiliation wicri:level="2">
<nlm:aff id="aff24">
<addr-line>Epidemiology and Prevention Branch, Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Epidemiology and Prevention Branch, Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia</wicri:regionArea>
<placeName>
<region type="state">Géorgie (États-Unis)</region>
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</author>
<author>
<name sortKey="Mounts, Anthony W" sort="Mounts, Anthony W" uniqKey="Mounts A" first="Anthony W." last="Mounts">Anthony W. Mounts</name>
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<addr-line>Global Influenza Programme, World Health Organization</addr-line>
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<wicri:noCountry code="subfield">World Health Organization</wicri:noCountry>
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</analytic>
<series>
<title level="j">PLoS Medicine</title>
<idno type="ISSN">1549-1277</idno>
<idno type="eISSN">1549-1676</idno>
<imprint>
<date when="2011">2011</date>
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</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p>This study analyzes data from 19 countries (from April 2009 to Jan 2010), comprising some 70,000 hospitalized patients with severe H1N1 infection, to reveal risk factors for severe pandemic influenza, which include chronic illness, cardiac disease, chronic respiratory disease, and diabetes.</p>
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</front>
<back>
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<li>Chili</li>
<li>Espagne</li>
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